Финансовые аспекты реформирования дошкольного образования (на примере МАДОУ ДСКВ №7 «Дарование»)

Актуальность работы тем, что в условиях нестабильной экономической ситуации в РФ и без того не слишком высокий уровень финансирования системы образования всех уровней имеет тенденции к снижению, так что образовательные учреждения вынуждены искать дополнительные (к бюджетному) источники финансирования, в том числе, за счет коммерческой деятельности. Объектом исследований является финансирование образовательной сферы РФ Предметом исследований является процесс реформирования и текущее состояние финансирования системы образования на примере МАДОУ ДСКВ №7 "Дарование". Целью ВКР является оптимизация финансовых аспектов реформирования дошкольного образования (на примере МАДОУ ДСКВ №7 "Дарование").The relevance of the work is that in the unstable economic situation in the Russian Federation, the already not too high level of funding for the education system at all levels tends to decrease, so that educational institutions are forced to look for additional (to the budget) sources of funding, including through commercial activities. The object of research is the financing of the educational sphere of the Russian Federation The subject of research is the process of reformation and the current state of financing of the education system on the example of MADOU DSKV №7 "Darovanie". The purpose of WRC is to optimize the financial aspects of reforming preschool education (on the example of MADOU DSKV №7 "Darovanie")

Isolated IgG4-related interstitial lung disease: unusual histological and radiological features of a pathologically proven case

IgG4-related lung disease is commonly associated with autoimmune pancreatitis. Recently, isolated IgG4-related interstitial lung disease (ILD) without other organ involvement has newly been reported in two cases with clinical features of nonspecific interstitial pneumonitis (NSIP). We report the first case of an isolated IgG4-related ILD in a 78-year-old man with dry cough and dyspnea, whose clinical findings proved to be different from NSIP. Serum IgG4 levels were increased. Chest CT scan revealed bilateral consolidations especially in the lower lobes, enlarged mediastinal and hilar lymph nodes and pleural effusions. Video-assisted thoracoscopic (VATS) lung biopsy revealed a pattern similar to usual interstitial pneumonia (UIP) and an abundant IgG4-positive plasma cell infiltration. He was effectively treated by steroid therapy. Increasing recognition of IgG4 related diseases has led to a growing number of new entities. The novel concept of isolated IgG4-related ILD as a pulmonary manifestation of a systemic IgG4-related disorder should be taken into account as a possible differential diagnosis of ILD and mass-forming lesions, even when no other organ manifestation is clinically apparent at the time of diagnosis. Lung specific diagnostic criteria and algorithms are required to enhance diagnostic accuracy in cases of possible IgG4-related ILD

Querying standardized EHRs by a Search Ontology XML extension (SOX).

Motivation: The previously developed Search Ontology (SO) allows domain experts to formally specify domain concepts, search terms associated to a domain, and rules describing domain concepts. So far, Lucene search queries can be generated from information contained in the SO and can be used for querying literature data bases or PubMed. However, this is still insufficient, since these queries are not well suited for querying XML documents because they are not following their structure. However, in the medical domain, many information items are coded in XML. Thus, querying structured XML documents is crucial for retrieving similar cases or for identifying potential study participants. For example, information items of patients with a similar tumor classification documented in a certain section of the respective pathology report need to be retrieved. This requires a precise definition of queries. In this paper, we introduce a concept for the generation of such queries using a Search Ontology XML extension to enable semantic searches on structured data. Results: For a gain of precision, the paragraph of a document need to be specified, in which a specific information item expressed in a query is expected to appear. The Search Ontology XML Extension (SOX) connects search terms to certain sections in XML documents. The extension consists of a class which represents the XML structure and a relation between search terms and this XML structure. This enables an automatic generation of XPath expressions, which makes an efficient and precise search of structured pathology reports in XML databases possible. The combination of standardized Electronic Health Records with an ontology based query method promises a gain of precision, a high degree of interoperability and long term durability of both, XML documents and queries on XML documents

Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas

In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss of chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18 (7/37 [19%]), and 14 (5/37 [14%]). Tumors with NF2 alterations exhibited overall increased chromosomal instability. Unsupervised clustering of DNA methylation profiles revealed separation into three groups: designated group 1 composed of clear cell and papillary meningiomas, whereas group 2A comprised predominantly atypical meningiomas and group 2B enriched for rare high-grade subtypes (rhabdoid, chordoid). Meningiomas from NF2 patients clustered exclusively within groups 1 and 2A. When compared with a dataset of 105 adult meningiomas, the pediatric meningiomas largely grouped separately. Targeted panel DNA sequencing of 34 tumors revealed frequent NF2 alterations, while other typical alterations found in adult non-NF2 tumors were absent. These data demonstrate that pediatric meningiomas are characterized by molecular features distinct from adult tumors

Multitrophic Interaction in the Rhizosphere of Maize: Root Feeding of Western Corn Rootworm Larvae Alters the Microbial Community Composition

BACKGROUND: Larvae of the Western Corn Rootworm (WCR) feeding on maize roots cause heavy economical losses in the US and in Europe. New or adapted pest management strategies urgently require a better understanding of the multitrophic interaction in the rhizosphere. This study aimed to investigate the effect of WCR root feeding on the microbial communities colonizing the maize rhizosphere. METHODOLOGY/PRINCIPAL FINDINGS: In a greenhouse experiment, maize lines KWS13, KWS14, KWS15 and MON88017 were grown in three different soil types in presence and in absence of WCR larvae. Bacterial and fungal community structures were analyzed by denaturing gradient gel electrophoresis (DGGE) of the 16S rRNA gene and ITS fragments, PCR amplified from the total rhizosphere community DNA. DGGE bands with increased intensity were excised from the gel, cloned and sequenced in order to identify specific bacteria responding to WCR larval feeding. DGGE fingerprints showed that the soil type and the maize line influenced the fungal and bacterial communities inhabiting the maize rhizosphere. WCR larval feeding affected the rhiyosphere microbial populations in a soil type and maize line dependent manner. DGGE band sequencing revealed an increased abundance of Acinetobacter calcoaceticus in the rhizosphere of several maize lines in all soil types upon WCR larval feeding. CONCLUSION/SIGNIFICANCE: The effects of both rhizosphere and WCR larval feeding seemed to be stronger on bacterial communities than on fungi. Bacterial and fungal community shifts in response to larval feeding were most likely due to changes of root exudation patterns. The increased abundance of A. calcoaceticus suggested that phenolic compounds were released upon WCR wounding

Domain Modeling and Application Development of an Archetype- and XML-based EHRS : Practical Experiences and Lessons Learnt.

Keywords Electronic health record, EHR standards, medical informatics applications, health infromation exchange, openEHR, XML Background Access to patient data within the hospital or between hospitals is still problematic since a variety of information systems is in use applying different vendor specific terminologies and underlying knowledge models. Beyond, the development of electronic health record systems (EHRSs) is time and resource consuming. Thus, there is a substantial need for a development strategy of standardized EHRSs. We are applying a reuse-oriented process model and demonstrate its feasibility and realization on a practical medical use case, which is an EHRS holding all relevant data arising in the context of treatment of tumors of the sella region. In this paper, we describe the development process and our practical experiences. Methods Requirements towards the development of the EHRS were collected by interviews with a neurosurgeon and patient data analysis. For modelling of patient data, we selected openEHR as standard and exploited the software tools provided by the openEHR foundation. The patient information model forms the core of the development process, which comprises the EHR generation and the implementation of an EHRS architecture. Moreover, a reuse-oriented process model from the business domain was adapted to the development of the EHRS. Results The reuse-oriented process model is a model for a suitable abstraction of both, modeling and development of an EHR centralized EHRS. The information modeling process resulted in 18 archetypes that were aggregated in a template and built the boilerplate of the model driven development. The EHRs and the EHRS were developed by openEHR and W3C standards, tightly supported by well-established XML techniques. The GUI of the final EHRS integrates and visualizes information from various examinations, medical reports, findings and laboratory test results. Conclusion We conclude that the development of a standardized overarching EHR and an EHRS is feasible using openEHR and W3C standards, enabling a high degree of semantic interoperability. The standardized representation visualizes data and can in this way support the decision process of clinicians

Using formal ontology for the representation of morphological properties of anatomical structures in endoscopic surgery

In this paper we present results to the problem of an adequate and compact symbolic representation of morphological features of anatomical structures that serve as surgical landmarks for automated assistance in endoscopic surgery using the General Formal Ontology (GFO) as a formal framework. For this purpose, we employed a translation from this first-order logic representation to a more compact description logic based formalism with the associated benefits, such as the availability of decidable reasoning procedures, for the purpose of automated landmark recognition in a hybrid symbolic/subsymbolic AI approach